Achieving High Sustained Viral Response in Difficult-to-Treat Hepatitis C-Infected Transfusion-Dependent Thalassemia Patients with Direct-Acting Antivirals
نویسندگان
چکیده
Background and Aim: Transfusion-dependent thalassemia (TDT) patients are at a high risk for contracting chronic hepatitis C. High viral load, hyperferritinemia, previous treatment exposure likelihood of cirrhosis make this group difficult to treat. This study aimed evaluate the efficacy directly acting antivirals (DAAs) in treating C infection TDT patients. Methods: with detectable HCV RNA were included study. The regimen was tailored based on genotype, treatment, presence cirrhosis. Sustained response (SVR) assessed by measuring levels three months after end treatment. Results: A total 20 mean age 18.25 years male-to-female ratio 3:1 treated DAAs. Genotype 3 most common (70%), followed genotype 1. average ferritin level 2751.10 ng/ml, load approximately 1.98 x 10ˆ7 IU/ml. Among patients, 10 had experience 4 cirrhosis, all whom relapsed interferon therapy. SVR achieved 19 out (95%). One patient 1, who previously received peg-interferon 2± ribavirin 48 weeks each, (ETR) but failed achieve SVR. After completion therapy, both serum ALT showed significant decline. No adverse effects observed use Conclusion: Despite poor predictive factors such as elevated levels, therapy relapse, DAAs resulted rate transfusion-dependent without any event.
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ژورنال
عنوان ژورنال: Journal of clinical and experimental hepatology
سال: 2023
ISSN: ['0973-6883', '2213-3453']
DOI: https://doi.org/10.1016/j.jceh.2023.07.234